A game played for the highest stakes also entails high risks ... In 1647, Alexis himself, at the age of eighteen, had chosen Euphemia Vsevolozhska to be his first wife. But when she was being dressed, a group of court ladies twisted her hair so tightly that in Alexis' presence she fainted. The court physicians were persuaded to declare that she had epilepsy, and she and her relatives were also dispatched to Siberia.
Peter the Great: His Life and World, by Robert K. Massie, Ballantine New York 1980.